Friday, November 30, 2012

Staying on Track with Accountability Partners | Financial Blogger

Our last few articles on the subject of credit and personal finance were so well received that we decided to expand the topic a little. If you?re looking for the best way to really kickstart things in terms of rebuilding your finances, the best advice that we can give is that you need to find accountability partners.

Even if you?re looking at credit counseling, this is a great way to make sure that you truly can stay the course. A good accountability partner has a few defining characteristics ? so we?ll go into those here right now.

First and foremost, you should be looking for someone who you respect. This might not just be a relative, but a friend that you have grown to know, like, and trust very deeply. The more that you trust your accountability partner, the more likely it is that you?re going to be honest with them. This should be obvious, but you really do have to be pretty transparent. If you aren?t following the roadmap that you set out, you should have your accountability partner call you out on it. But if you end up just lying your way through it, then they aren?t going to stand by you. Why would you want to waste their time with lies when you could let them go and enjoy the rest of their life without having to try to drag you along? It?s your financial future, not theirs.

Make sure that you can set up a realistic time schedule to meet with them. Your support buddy is going to have their own life to tend to, with their own set of financial problems to work through. You don?t want to push all of your issues onto them, right? So you just need to make sure that you are always thinking about the road ahead of you, no matter what. It can be problematic, but it?s always worth it in the long run.

Even though your friend is working with you to give you support, you should still make sure that you?re following your own thoughts and dreams. Everyone will have unique goals that they want, in their own timeframe. If your support buddy isn?t working for you, don?t hesitate to get another one. After all, life is way too short to let everything start bothering you. It would be a lot easier to move forward and really think about how good you?re going to feel at the end of the path in front of you.

Whether you want to get out of debt, start a business, or even just be able to do more with your life in general, having support behind you is definitely the best way to go ? check it out today!

from your own site.

Source: http://www.financialblogger.co.uk/staying-on-track-with-accountability-partners/

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A very Biden Christmas (Washington Bureau)

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Manchester Professor elected a Fellow of the AAAS

Manchester Professor elected a Fellow of the AAAS [ Back to EurekAlert! ] Public release date: 30-Nov-2012
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Contact: Daniel Cochlin
daniel.cochlin@manchester.ac.uk
0044-161-275-8387
University of Manchester

Douglas Kell, Professor of Bioanalytical Science in the School of Chemistry and the Manchester Institute of Biotechnology, was elected to the prestigious body, which is an honour bestowed upon AAAS members by their peers.

This year 702 members have been awarded this honor by AAAS because of their scientifically or socially-distinguished efforts to advance science or its applications. Professor Kell is one of fewer than 50 UK scientists of nearly 8,000 Fellows recorded on the AAAS website to hold this honour.

New Fellows will be presented with an official certificate and a gold and blue rosette pin, representing science and engineering respectively, on Saturday, 16 February at the AAAS Fellows Forum during the 2013 AAAS Annual Meeting in Boston, Massachusetts.

This year's AAAS Fellows will be formally announced in the AAAS News & Notes section of the journal Science on 30 November 2012.

Professor Kell, who is also the Chief Executive of the Biotechnology and Biological Sciences Research Council (BBSRC), focuses on the development and application of novel analytical methods to the solution of complex biological problems.

As one of the Biological Sciences nominees, Professor Kell was elected for his "distinguished contributions to quantitative and systems biology and analytical biotechnology, and for service as CEO, Biotechnology and Biological Sciences Research Council, UK."

Professor Kell said: "I am delighted to have been recognized by my peers, and for the great honour of being elected a Fellow of AAAS.

"This recognition is a notable reflection of the work I have been doing here at The University of Manchester, and also at the BBSRC.

"AAAS is a hugely prestigious organisation which is instrumental in the advancement of science and works tirelessly to promote scientific excellence throughout the world."

The tradition of AAAS Fellows began in 1874. Currently, members can be considered for the rank of Fellow if nominated by the steering groups of the Association's 24 sections, or by any three Fellows who are current AAAS members (so long as two of the three sponsors are not affiliated with the nominee's institution), or by the AAAS chief executive officer.

Each steering group then reviews the nominations of individuals within its respective section and a final list is forwarded to the AAAS Council, which votes on the aggregate list.

The Council is the policymaking body of the Association, chaired by the AAAS president, and consisting of the members of the board of directors, the retiring section chairs, delegates from each electorate and each regional division, and two delegates from the National Association of Academies of Science.

###


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Manchester Professor elected a Fellow of the AAAS [ Back to EurekAlert! ] Public release date: 30-Nov-2012
[ | E-mail | Share Share ]

Contact: Daniel Cochlin
daniel.cochlin@manchester.ac.uk
0044-161-275-8387
University of Manchester

Douglas Kell, Professor of Bioanalytical Science in the School of Chemistry and the Manchester Institute of Biotechnology, was elected to the prestigious body, which is an honour bestowed upon AAAS members by their peers.

This year 702 members have been awarded this honor by AAAS because of their scientifically or socially-distinguished efforts to advance science or its applications. Professor Kell is one of fewer than 50 UK scientists of nearly 8,000 Fellows recorded on the AAAS website to hold this honour.

New Fellows will be presented with an official certificate and a gold and blue rosette pin, representing science and engineering respectively, on Saturday, 16 February at the AAAS Fellows Forum during the 2013 AAAS Annual Meeting in Boston, Massachusetts.

This year's AAAS Fellows will be formally announced in the AAAS News & Notes section of the journal Science on 30 November 2012.

Professor Kell, who is also the Chief Executive of the Biotechnology and Biological Sciences Research Council (BBSRC), focuses on the development and application of novel analytical methods to the solution of complex biological problems.

As one of the Biological Sciences nominees, Professor Kell was elected for his "distinguished contributions to quantitative and systems biology and analytical biotechnology, and for service as CEO, Biotechnology and Biological Sciences Research Council, UK."

Professor Kell said: "I am delighted to have been recognized by my peers, and for the great honour of being elected a Fellow of AAAS.

"This recognition is a notable reflection of the work I have been doing here at The University of Manchester, and also at the BBSRC.

"AAAS is a hugely prestigious organisation which is instrumental in the advancement of science and works tirelessly to promote scientific excellence throughout the world."

The tradition of AAAS Fellows began in 1874. Currently, members can be considered for the rank of Fellow if nominated by the steering groups of the Association's 24 sections, or by any three Fellows who are current AAAS members (so long as two of the three sponsors are not affiliated with the nominee's institution), or by the AAAS chief executive officer.

Each steering group then reviews the nominations of individuals within its respective section and a final list is forwarded to the AAAS Council, which votes on the aggregate list.

The Council is the policymaking body of the Association, chaired by the AAAS president, and consisting of the members of the board of directors, the retiring section chairs, delegates from each electorate and each regional division, and two delegates from the National Association of Academies of Science.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/uom-mpe113012.php

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The Upside-Down World of Catholic Higher Education | Crisis ...

U of San Diego PIC

In an ideal Catholic world, if a Catholic theologian promoted a woman?s right to choose abortion and encouraged access to same-sex marriage, while also comparing the sacrifice of the Mass to an act of homosexual intercourse, the work of that theologian would be marginalized. But, in the upside-down world of Catholic higher education in 2012, such dissidence is applauded. Case in point: Tina Beattie, the British theologian whose book, God?s Mother, Eve?s Advocate: A Gynocentric Refiguration of Marian Symbolism in Engagement with Luce Irigaray, promotes such heresy, has been honored as a visionary on Catholic campuses here and abroad.

Conflict and confusion at the University of San Diego
However, after a decade of honors and accolades from Catholic institutions, Beattie?s writings are finally receiving some criticism. In 2011, Bishop Declan Lang, of the Diocese of Clifton in the UK, canceled a lecture to be given by Beattie as part of a diocesan speaker series celebrating the 50th anniversary of the Second Vatican Council. And last month, Beattie?s invitation to serve as a visiting fellow at the University of San Diego?s Frances G. Harpst Center for Catholic Thought and Culture brought protests from the Catholic community in San Diego and beyond. In fact, the protests were so strong that Mary Lyons, the university?s president, abruptly withdrew the invitation just two weeks before Beattie was scheduled to arrive on the USD campus.

Lyons? decision to cancel the Beattie fellowship resulted in a vote of ?no confidence? from 99 members of the university?s Academic Assembly of the College of Arts and Sciences (the vote was 99 in support, 16 against, and 19 abstentions). Writing that ?[t]he president has shown herself to be ethically bankrupt,? the 99 faculty members claimed that their vote ?lets the world know that faculty here do in fact support and believe strongly in academic freedom?this body declares a loss of confidence in [Lyons?] leadership.?

In explaining her decision, Lyons distributed a letter to the University of San Diego community claiming that Beattie ?has taken positions that many would say challenge Church teachings.?? And although Lyons stops short of stating she herself would ever claim Beattie challenged Church teachings, the USD president also said that ?offering [Beattie] an honorary fellowship would be a betrayal of those benefactors who supported the Center.? Pointing out that the Center was designed and funded by generous men and women who wanted to present the Catholic tradition ?with accuracy and respect,? Lyons made the decision to rescind the invitation. In a letter to the chair of the Academic Assembly, Lyons wrote that she would allow Beattie to speak at the university in the spring semester as long as the theologian was not given an ?honorary affiliation? with the institution?a reference to Beattie?s expected title of visiting fellow.

The real question is this: Why has Beattie?a theologian who has denigrated the teachings of the Church for more than a decade?been given so many honors in the first place? As the Professor of Catholic Studies at Roehampton University, Beattie serves on the board of and is a frequent contributor to The Tablet, a British Catholic weekly journal which describes itself as ?committed to the teaching of the Second Vatican Council.? Consistently criticizing the Magisterium, Beattie is an advocate for a woman?s right to choose abortion. In a 2010 article published in The Tablet titled ?In the Balance: Morality of Abortion,? Beattie calls abortion ?the lesser of two evils.? Claiming that women have the right to choose abortion, Beattie writes, ?It is to my mind unacceptable in today?s world that a religious hierarchy made up exclusively of celibate men should claim the right to make authoritative decisions regarding these most intimate areas of women?s lives.?

In a speech titled ?How Far Can You Go?? delivered at the conference for the Movement for Married Clergy in London in 2006, Beattie dismisses the ?gendered nuptial sacramentality in which the relationship between Christ the Bridegroom and the Church as Bride is played out in the Mass.? Calling this relationship a ?cultic understanding of priesthood,? Beattie argues, ?Being a bridegroom certainly did not translate directly into Christ having to be a body with a penis.? For Beattie, ?we might learn from our Anglican brothers and sisters that the crisis in priesthood is not resolved by the ordination of married men nor even of women, unless we also address the question of where the homosexual person belongs in relation to the body of Christ.?

Beyond the dissidence, Beattie?s convoluted text itself should have excluded her from publishing in the first place. But, publishers like Continuum?publisher of God?s Mother, Eve?s Advocate?are always welcoming to those willing to disparage the male priesthood and the teachings of the Catholic Church on marriage and sexual morality. Most presses?without a political agenda?would be reluctant to publish a manuscript as jargon-laden as the one Beattie published with Continuum. This is just one example of Beattie?s pretentious prose?in this case, explaining to the reader why she is writing her book:

My intention is to liberate the theological language of maternal femininity from the colonizing discourses of masculinity, by mimetically assuming the position of the theoretical Catholic woman as well as being a Catholic woman theorist. As a Catholic theologian, I don the masks and adopt the strategies of Irigarayan woman in order to see Mary differently?.

And so forth.

A history of honoring dissident theologians at USD
Still, it is understandable that the University of San Diego?s faculty members were shocked and angered by their president?s decision, considering the fact that throughout the past two decades, they have succeeded in honoring some of the most dissident theologians in the country. In 2008, USD honored Father Peter Phan, professor of theology at Georgetown University and former president of the Catholic Theological Society of American, despite his precarious status as a theologian under investigation by the Vatican and the US bishops for his view that Jesus is but one among many paths to salvation.

In 2007 the Vatican?s Congregation for the Doctrine of the Faith criticized Father Phan?s 2004 book Being Religious Interreligiously as ?notably confused on a number of points of Catholic doctrine and also contains serious ambiguities.? Claiming that there is a ?gnostic tenor running through the book,? the CDF also charges that Phan?s book can be read as suggesting that ?non-Christian religions have a positive role in salvation history in their own right and are not merely preparation for the Christian Gospel; that it makes little sense to try to convert non-Christians to Christianity; that it would be better to avoid terms such as ?unique,? ?absolute,? and ?universal? for the saving role of Jesus Christ; that the Holy Spirit operates in a saving way in non-Christian religions; that the Catholic Church cannot be identified with the church of Christ; and finally, that God?s covenant with the Jewish people does not find its completion in Jesus Christ.?

The United States Conference of Catholic Bishops concurred with these Vatican observations?especially concerns over Phan?s treatment of ?the uniqueness of Jesus Christ and the universality of his salvific mission, the salvific significance of non-Christian religions, and the uniqueness of the church as the universal instrument of salvation.?

The practice of awarding endowed chairs in theology at Catholic universities has actually provided the needed cover enabling faculty members to hire theologians without going through the same kinds of national-search protocols that hiring an assistant professor might require. At the University of San Diego, current theology faculty members have, on several occasions, invited former colleagues or their own professors from graduate school to fill distinguished chairs at the university. The first person to hold the Distinguished Msgr. John Portman Chair of Systematic Theology in 2001 was retired Archbishop of San Francisco John R. Quinn, whose book on the reform of the papacy calls for decreased papal authority, decentralization, more control granted to bishops, and parishioner involvement in the selection of bishops. Implementing Archbishop Quinn?s suggestions would bring the Catholic Church in line with most Protestant denominations and radically weaken the papacy. Yet he was honored with the endowed chair on the Catholic campus.

Invited to teach undergraduate theology students at the University of San Diego, Quinn has openly criticized, in his writings and speeches, the Roman Curia for ?wanton disregard? of the local Church, and ?blind, rigid application of Church law,? arguing that the Vatican should reopen discussion of such issues as the ordination of women, birth control, and married priests.? In May 1999, the Catholic newspaper San Francisco Faith reported that at a meeting of US bishops in Washington, DC, then-Archbishop Quinn called for rejection of Ex Corde Ecclesiae. Although Quinn resigned from his position as archbishop of San Francisco in 1995 at age 66, nine years earlier than the mandatory retirement age of 75, the University of San Diego welcomed the longtime critic of Ex Corde Ecclesiae and the papacy itself as the first recipient of the prestigious Portman Chair.

Quinn?s appointment seemed to set the pattern of inviting dissident theologians to hold the Portman Chair, as subsequent chair-holders have similarly negative views of papal authority, and have criticized Catholic Church teachings on reproductive rights and the role of women in the Church. For example, the 2002 chair-holder, Peter Hunerman, professor emeritus of? Catholic theology at the University of Tubingen, believes that barring women from ordination in the Catholic Church is based on ?undefensible premises.? In 2003, Father Bernard Marthaler, OFM, a professor of religion and religious education at Catholic University of America, was invited to hold the Portman Chair. A proponent of the ?new catechetics movement,? which privileges personal experience over formal Church teachings and dismisses ?book-centered catechesis? as filled with what he called ?tired customs and trite devotions,? Marthaler was one of the 87 original dissenters who joined with Charles Curran in 1968 to protest against the papal encyclical on birth control, Humanae Vitae. Yet, unlike Father Curran, Marthaler faced no disciplinary action and not only maintained his tenured position at Catholic University, but was invited to hold the prestigious chair at the University of San Diego for a year.

Following Marthaler, Mary Hines and Thomas Franklin O?Meara, both Rahner scholars, each held the Portman Chair. While Mary Hines questions the sanctified role of the Blessed Virgin Mary,? Father O?Meara, a retired theology professor from Notre Dame, dismissed what he called the ?trappings and autocracy of the Vatican bureaucracy.? O?Meara published an article in which he decried the hierarchy of the Church and applauded the fact that ?the baroque period in Catholicism is past.? And, in a speech at the Newman Theological College, O?Meara lashed out at the Vatican for banning discussion on the ordination of women, suggesting that ?the ordination of married men to the priesthood and of women to the diaconate is only a matter of time.? Dismissing Catholic teachings on women?s ordination, O?Meara claims that ?it is hard to argue that women should not have public roles because the Holy Spirit doesn?t discriminate on the basis of biology.?

More recently, Father James Keenan, SJ was awarded the Portman Chair last year. Currently serving as the Founders Professor of Theology at Boston College, Keenan made headlines in 2003 when he appeared before the joint committee on the judiciary for the state of Massachusetts to offer his support for same-sex marriage. The judiciary was debating a bill (constitutional amendment H3190) that would mandate that only the union of one man and one woman be recognized as a marriage in Massachusetts. Claiming to present the Catholic perspective, Keenan claimed that ?H3190 is contrary to Catholic teaching on social justice.? The Catholic theological tradition stands against the active and unjust discrimination against the basic social rights of gay and lesbian persons.? Keenan encouraged legislators to vote against a bill that would ban same-sex marriages.

Beyond the Portman Chair, visiting professors to USD constitute a long tradition of encouraging those with pluralist views of Church teachings to teach undergraduates. Theologian Bernard Cooke, a longtime visiting professor (and the former professor and colleague of a San Diego faculty member) who recently retired from USD, is one of the best-known dissenting theologians today. With a national reputation for criticizing Church teachings on priestly celibacy, divorce and remarriage, homosexuality, contraception, and women?s ordination, Cooke is a former Jesuit priest who left the priesthood three decades ago to marry, and has been critical of the current status of the priesthood ever since. Going well beyond the usual left-wing dissidence on sexual morality and reproductive choice, Cooke has been especially critical of the elevated status of ordained priests, and in his book, The Future of the Eucharist, Cooke claims that although a liturgical leader may preside, ?it is the community that celebrates the Eucharist.? In a lecture on the USD campus, Cooke claimed that ?the existence of a socially privileged group [priests] within the Church is not meant to be.? I hope that in a relatively short time, the inappropriate division between clergy and laity will vanish.?

Criticism of the status of priests within the Church has characterized Cooke?s career for the past 30 years. Claiming that the growing shortage of priests will lead to a ?liturgical starvation? for an expanding US Catholic population, Cooke?s solution is to empower the laity and allow married priests (or ex-priests, like him) to assume leadership. A member of CORPUS, an advocacy organization of former priests that lobbies for optional celibacy for Catholic clergy, Cooke is also a board member for Call to Action, a lay movement demanding women?s ordination, an end to priestly celibacy, and a change in the Church?s teachings on sexual morality.

Earlier this year, former Jesuit priest Paul Lakeland, a Fairfield University Catholic Studies professor, was invited to give an address to students and faculty at the University of San Diego. He received this honor despite the fact that in 2007 he was the media spokesman in favor of Connecticut Bill 1098, a bill that would have forced Catholic churches to reorganize along state-mandated lines?giving lay control over parishes and effectively removing the authority of priests and bishops. As a spokesman in favor of the bill, Lakeland, like Cooke, has long lobbied for an end to what? he calls the ?structural oppression of the laity? by the clergy. In his books (published by Continuum) and speeches, Lakeland promises to help all Catholics ?exercise their baptismal priesthood? and dismisses the role of the Catholic deacon as a ?monster? which belongs to a ?lay-ecclesial species.? Claiming that his newest book identifies the task of the laity as working ?to build a non-clerical Church,? Lakeland joins others in organizations like CORPUS and similar fringe Catholic groups to radically change the Church and marginalize the bishops? teaching authority on issues like abortion, same-sex marriage, and women?s ordination. Earlier this week, Lakeland wrote a letter to President Lyons decrying her decision to rescind the invitation to Beattie (published on the ?support Tina Beattie? website).

The renunciation of Church authority
One of the reasons theologians have confidently challenged the teaching authority of the Catholic Church is that many of those theologians, such as Nicholas Healy?a former Dean of Arts and Sciences at the University of San Diego who currently teaches at St. John?s University in New York?believe that theologians already comprise an ?alternative? magisterium:

No single authority trumps the others so that one could say that it is the decisive authority on which all the others rest. Certainly the bishops and popes are weighty authorities. They have something of a US Supreme Court or British lords? function in that they are to make the final authoritative judgment in cases of controversy. But only that: their teaching itself is not final in the sense that it halts or inhibits further debate on the same matters. For all their judgments must be interpreted and those interpretations discussed by the other magisterium, that of the theologians. (Nicholas M. Healy, ?By the Working of the Holy Spirit,? The Anglican Theological Review [Winter, 2006])

Rather than recognizing the authority of the Magisterium, theologians like Beattie, Lakeland, Cooke, and others favor a critical approach to Catholic theology that is rooted in the ?acceptance of experience as a legitimate source for theological reflection??and includes what some left-leaning theologians call a ?hermeneutics of suspicion to the sources and questions of theology,? as ?pluralism? is now the hallmark of progressive Catholic theology. Unlike those with an orthodox perspective of theology, these theologians have embraced the Enlightenment?s philosophical ?turn to the subject.? Such a development undermines the notion of a divine, supernatural revelation operating independently of human reason.

In contrast to Pope John Paul II and Benedict XVI, who have often cautioned against trusting personal experience, liberal theologians argue that revelation and the inspiration of the Holy Spirit can be discerned only from within human experience. These theologians claim that their position is grounded in Vatican II?s definition of the Church as the people of God (Lumen Gentium), and is consonant with an empowered laity whose experience must be considered along with that of the ordained as the Church moves forward in history.

Such a pluralistic approach to theology points to what liberal theologians view as a need to reflect on lived experience as a source for the renewal and strengthening of the Church. As self-described liberal academic theologians, Mary Ann Hinsdale, Chair of Theology at the College of the Holy Cross, and theology professor emeritus John Boyle write in the book What?s Left? Liberal American Catholics:

We can point to the appeal made to the experience of married Christians in the discussion of acceptable ways of preventing pregnancy prior to Humanae Vitae, and in the critical way in which the encyclical was received by many lay men and women.? In the decades since 1968, other issues of sexual morality, such as abortion and homosexuality, have been dealt with in Church teaching documents, to be met with similar appeals to the experience of Christians in the formation of the believer?s conscience.

Such an experiential approach to theology raises theological questions about the status of tradition and authority within the Church. For theologians like Hinsdale, Boyle, and others, the experience of the individual is of primary importance. From this perspective, if an individual woman feels called to the priesthood, or called to an abortion, then her call to priestly ordination, or to terminate a pregnancy, should take precedence over any Church teaching. For liberal theologians, ?the refusal of those in authority to attend to the experience of Christian believers raises questions about the fundamental fairness of the Church?s processes in dealing with disputes over doctrine or moral teachings.? Liberal theologians claim that from the ?critical theology? perspective, ?when the Church ignores the experience of its members, it tends to impoverish the perspectives available to enrich the theological task.?

A small but encouraging step
In an interview published in the National Catholic Reporter, Beattie warns that the cancellation of her fellowship was ?symptomatic of something very new and very worrying. It?s unheard of, certainly in Britain, for a theologian in my position to feel threatened by this kind of action?it?s not about me, it?s about some change in the culture of the Catholic Church that we should be very, very concerned about.?

For faithful Catholics, it is a hopeful sign that Beattie?s appointment was cancelled. Faithful Catholics have been concerned about theologians like Beattie for more than 50 years now. And, although financial concerns may have prompted President Lyons to cancel Beattie?s fellowship, the fact that it was cancelled at all is a step in the right direction.

This essay first appeared November 16, 2012 in Catholic World Report and is reprinted with permission.

Source: http://www.crisismagazine.com/2012/the-upside-down-world-of-catholic-higher-education

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10 Things to Know for Thursday

Your daily look at late-breaking news, upcoming events and stories that will be talked about Thursday:

1. WHAT PALESTIANIANS ARE POISED TO GAIN FROM THE UN

Thursday's vote on recognizing a Palestinian state could give them leverage in future border talks with Israel.

2. RUSH TOWARD 'FISCAL CLIFF' SLOWS A SMIDGE

The White House and a key Democrat hint at concessions on taxes and cuts, while more Republicans seem ready to give ground.

3. HOW THE POWERBALL JACKPOT GOT SO BIG

Nationwide, about 130,000 tickets were sold each minute Wednesday ? about six times the rate from a week ago ? fattening the prize.

4. GOP LAWMAKERS STILL NOT BUYING WHAT SUSAN RICE IS SELLING

As she trods an uphill path in pursuit of secretary of state's job, Obama, at least, remains solidly in support.

5. IN EGYPT, FEARS OF A 'SECOND REVOLUTION'

President Morsi faces an unprecedented strike by the courts and massive opposition protests after his decrees placing him above oversight of any kind.

6. OBAMA TO ROMNEY: LET'S DO LUNCH

The political rivals will break bread Thursday at the White House. It'll be their first meeting since the election.

7. TRIAL FOCUSES ON 'DEATH FLIGHTS' DURING ARGENTINA DICTATORSHIP

Pilots are accused of flying missions during which political prisoners, drugged to sleep, were thrown alive into the sea.

8. WHY GOTHAM'S GLOWING A BIT BRIGHTER

Some 30,000 bulbs festooning the 80-foot Christmas tree in NYC's Rockefeller Center are now beaming forth.

9. IMAGINE! YOKO ONO'S FASHIONS INSPIRED BY JOHN LENNON'S 'HOT BOD'

Her new menswear collection includes pants with large handprints on the crotch, tank tops with nipple cutouts and a flashing LED bra.

10. DOPING ALLEGATIONS CAST SHADOW OVER HALL OF FAME BALLOT

Recent history suggests that the odds are against Barry Bonds, Roger Clemens and Sammy Sosa making it to Cooperstown.

Source: http://news.yahoo.com/10-things-know-thursday-104756375.html

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Thursday, November 29, 2012

You Can?t Wrap an E-Book

It used to be easy to give your loved ones books for the holidays. You went to a bookstore, browsed the shelves , and picked out something thoughtful: Jodi Picoult?s latest for your mom, Harry Potter for your niece, maybe a Bill O?Reilly rant for that uncle who never shuts up at Thanksgiving.
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But now everyone has a Kindle or a Nook or an iPad. And how do you give an e-book? Sure, you can just hand over a gift card. But where?s the fun in that? Here are nine ideas for turning an e-book into a gift you can wrap up and tuck under the tree.

Source: http://feeds.slate.com/click.phdo?i=48c187fae0af6532b424c1c71a0a8fa4

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Amazon?s S3 Now Stores Over 1.3 Trillion Objects, 3.7 Million Elastic Map Reduce Clusters Launched Since May 2010

re-invent-amazonAt Amazon's first re: Invent developer conference in Las Vegas today, the company's vice president for Amazon Web Services Andy Jassy announced that its S3 storage service now stores a total of 1.3 trillion objects and handles over 830,000 requests per second. Jassy also announced that the?company's?users spun up 3.7 million Elastic Map Reduce clusters since the service launched in May 2010.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/BYQYls8C-hk/

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OilVoice Morning Movers - Leyshon Resources, Amerisur Resources and Mercom Oil Sands

Wednesday, November 28, 2012

Leyshon Resources (LON:LRL) announced this morning that the ZJS5 well in the Ordos Basin had "potential to flow gas at commercial rates". The company said that analysis of the logs and samples was ongoing, however, initial results have indicated that about 56.4 metres pay intervals have been encountered.

Managing Director Paul Atherley said: 'Frank Fu and his team have celebrated joining Leyshon by continuing their remarkable recent drilling success in the region with extremely encouraging logging results from the first well. We are very much looking forward to the flow test results on the multiple prospective pay zones over the next few weeks.

The Ordos Basin is the beating heart of Central China, the world's fastest growing major economy and is quite simply one of the best places in the world to be discovering gas right now.

Any commercial gas discovery at Zijinshan will be hooked into one of the nearby pipelines and sold into one of the world's fastest growing markets for gas.'

Broker FoxDavies said: 'With the second well expected to spud shortly, we expect the rate of potential catalyst points, as provided by news flow, to increase as time progresses.'

Leyshon Resources are currently trading at 20.27 pence a share, down 20.49% on opening.

Amerisur Resources (LON:AMER) announced this morning that the fourth well on the Platanillo field in Colombia has been successfully drilled to a total depth of 8,689 feet.

Amerisur Resources are currently trading at 43.50 pence a share, down 1.14% on opening.

Mercom Oil Sands (LON:MMO) shares have fallen by 7.69% this morning and are currently trading at 1.50 pence a share.

This article is for information and discussion purposes only and does not form a recommendation to invest or otherwise. The value of an investment may fall. The investments referred to in this article may not be suitable for all investors, and if in doubt, an investor should seek advice from a qualified investment adviser. More

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Source: http://www.oilvoice.com/n/OilVoice_Morning_Movers_Leyshon_Resources_Amerisur_Resources_and_Mercom_Oil_Sands/2e245a9ed378.aspx

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Obama: Pass my tax plan (CNN)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/267064364?client_source=feed&format=rss

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Facebook Gives New Mobile Page Ads More Color And Context To Make Every Pixel Count

Facebook New Mobile Page Ads DesignYou scrolled right past the old design for Facebook's "Pages You Might Like" mobile ads. Too much gray, not enough description. But they just got updated to show colorful banners and explain what a business does. Their designer Jeff Kanter thinks you'll stop to give them a look. Maybe even a tap. With style and targeting, Facebook is turning limited mobile ad space into its secret weapon.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/pxp_UST0iq4/

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Salma Hayek - British Fashion Awards in London

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Philanthropist Wants 'Book Revolution' in Vietnam (Voice Of America)

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Wednesday, November 28, 2012

A rather thin and long new snake crawls out of one of Earth's biodiversity hotspots

ScienceDaily (Nov. 27, 2012) ? Field and laboratory work by a group of zoologists led by Omar Torres-Carvajal from Museo de Zoolog?a QCAZ, Pontificia Universidad Cat?lica del Ecuador, has resulted in the discovery of a new species of blunt-headed vine snake from the Chocoan forests in northwestern Ecuador. This region is part of the 274,597 km2 Tumbes-Choc?-Magdalena hotspot that lies west of the Andes.

The study was published in the open access journal ZooKeys.

Blunt-headed vine snakes live in an area comprising Mexico and Argentina, and are different from all other New World snakes in having a very thin body, disproportionately slender neck, big eyes, and a blunt head. They live in trees and hunt frogs and lizards at night. The new species described by Torres-Carvajal and his collaborators was named Imantodes chocoensis and increases the number of species in this group of snakes to seven.

Snakes collected as far back as 1994 and deposited in several Ecuadorian and American natural history museums were also examined. The authors were soon surprised with an interesting discovery. Some individuals from the Ecuadorian Choc? lacked a big scale on their face that is present in all other blunt-headed vine snakes from the New World. Other features, as well as DNA evidence, indicate that these Chocoan snakes actually belong to a new species. DNA data also suggest that its closest relative is a species that inhabits the Amazon on the other side of the Andes.

'One possible explanation for the disjunct distribution between the new species and its closest relative is that the uplift of the Andes fragmented an ancestral population into two, each of which evolved into a different species, one in the Choc? region and the other in the Amazon' said Dr Torres-Carvajal.

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The above story is reprinted from materials provided by Pensoft Publishers, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Omar Torres-Carvajal, Mario Yanez, Diego Quirola, Eric N. Smith, Ana Almend?riz. A new species of blunt-headed vine snake (Colubridae, Imantodes) from the Choc? region of Ecuador. ZooKeys, 2012; 244 (0): 91 DOI: 10.3897/zookeys.244.3950

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/fTT8lyKyB_c/121127101536.htm

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The Board Game Family Top 10 Best Board Games - Caleb ? The ...

CalebCaleb is our ?go to? board game player. If you?re ever in the mood to play a board game or a card game, you?ll find an eager player in Caleb. Mention playing a game and he?ll be right there. In fact, if you delay even a bit after mentioning playing a game, chances are good that he?s already got a game out, set up, cards dealt out and ready to play.

And if others are playing a game, he?ll sniff it out and quickly be pegged to the table asking to join in or challenging the winner to the next game.

But even with how much he loves playing all types of games, he also has his favorites.

After playing hundreds of games, here?s the list of board games that Caleb (currently age 9) thinks are the best. (Don?t be surprised when you see half of them also on Jaden?s list. When brothers love the same games, I call that a success.)

Thunderstone

Thunderstone Advance card gameCaleb liked Thunderstone right from the start. I?m pretty sure the fantastic artwork has a lot to do with it. Great graphics have a way of pulling players into the theme and spirit of a game. And the art in Thunderstone definitely does it?s job well. Add to that the fact that you get to recruit and level-up cool heroes, equip them with awesome weapons and send them off to battle a wide variety of monsters in the dungeon and you?ve got a young boy thoroughly wrapped up in the game. He doesn?t care that the box says ages 12+, he loves Thunderstone. This was an easy pick for Caleb.
See our full review of Thunderstone.

Small World

Smallworld board gameLike his older brothers, I knew that Small World would be on Caleb?s list. With the random combinations of races and abilities every time you play, it?s no surprise they all love Small World. Of course, it goes without saying that they also like attacking each other. They also like trying to get everyone to gang up on someone other than themselves. They can plead their case pretty convincingly as they try to expand without hindrance. I can?t imagine a game of Small World ever being turned down by any of them. This board game will be easily accessible on the game shelf for a very long time.
See our full review of Small World.

Fastrack

Fastrack board gameCaleb loves to challenge Jaden playing Fastrack. Since Jaden has crowned himself the ?King of Fastrack?, Caleb feels the constant need to seek to de-thrown him. Occasionally he gets a win in. And when he does, you?ll hear the hootin? and hollerin? throughout the house. Aren?t brotherly challenges grand?
Of course, Caleb?s quick finger flicking can beat most others on a regular basis, so it shouldn?t be a surprise to see this quick-playing game on his list.
See our full review of Fastrack.

Dominion

Dominion card gameThough similar to Thunderstone, Dominion doesn?t have the dripping theme of heroes and monsters. But that doesn?t stop Caleb from loving Dominion as well. Dominion is the first of the deck-building games published and is still the king. Many games have come after trying to copy the success of Dominion. But the simplicity of the original is hard to beat. It?s also so addicting and hugely expandable that it?s hard to get tired of it. And Caleb?s a very formidable opponent in Dominion so don?t be thrown off by his age, he knows what he?s doing.
See our full review of Dominion.

Yinsh

Yinsh board game boxI was surprised to see Yinsh on Caleb?s Top 10 list. It?s not that he doesn?t enjoy it, but he hasn?t hit his stride with it yet. He does love looking ahead a few moves to plan out how he?s going to get 5 in a row. But he hasn?t quite understood the need to adjust his strategy as the game progresses and the other player sets up their own move. But I think with every play he?s beginning to watch out a little more. It?s great to see his thought process develop as he plays this great 2-player abstract strategy game.
See our full review of Yinsh.

Ninja Versus Ninja

Ninja versus Ninja board gameIt?s time to depart from some of the games on Jaden?s favorites list and get to one of the games Caleb uniquely loves. Ninja Versus Ninja is another 2-player board game that matches players in a head-to-head battle. The playing pieces are fantastic and it?s hard to find cooler dice in a kids board game. Players try to sneak into their opponent?s dojo and get safely back. The deeper they go into the dojo and make it out again, the more points they?ll get. Of course, players can also win by eliminating all their opposing ninja ? which is perhaps Caleb?s favorite way of winning.
See our full review of Ninja Versus Ninja.

Pirate Versus Pirate

Pirate Versus Pirate board gameRemember what I said about it being hard to find cooler dice in a kids board game. Well, Pirate Versus Pirate is right on par with Ninja Versus Ninja. The difference being a bone sticking through the dice (if you can call them dice) rather than a sword. The two games are similar but different enough to present their own challenges. Pirate Versus Pirate is a 3-player game and best played with exactly that. The board is also split into triangle spaces which makes moving around and landing on the other player pieces to eliminate them a bit tougher. It also has the unique 3-player dynamics of either targeting one player or two people battling while the 3rd sneaks away with the treasure almost uncontested. Makes for some good strategy with a bunch of luck in the dice rolls.
See our full review of Pirate Versus Pirate.

Knock Your Blocks Off

Knock Your Blocks Off board gameIt?s easy to see why Caleb loves Knock Your Blocks Off ? he gets to destroy things. When given a game that has a main objective of destroying an opponent?s structure, you can be sure to count him in. The twist on the destruction portion of the game is that players roll a die to see how they get to attempt the destruction. But destroying isn?t the only part of the game. Players have to first build something as quickly as they can. If they?re the first to build their structure, they also get a point. And Caleb?s pretty quick.
See our full review of Knock Your Blocks Off.

7 Wonders

7 Wonders card game7 Wonders is another game where the suggested age on the box is no match for Caleb. With all the different card types and symbols and the various paths to score victory points, there?s a lot to keep track of in the game. Perhaps that?s why he likes it so much ? it keeps his mind moving the whole time thinking through his strategy and deciding which cards to choose each turn. He?s also good at keeping an eye on his neighbors, their goods, and their military might so he knows when to strike and when to keep a card from passing on. No going easy on him.
See our full review of 7 Wonders.

The Big Fat Tomato Game

The Big Fat Tomato Game board gameThe Big Fat Tomato Game is a relatively new entry into our board game collection, yet has won over Caleb enough to put it in his Top 10 list. It?s a very straight forward game about harvesting tomatoes while defending your patch from a garden variety of intruders like weeds, varmints, and even the tomato zombie. There?s a wide variety of cards in the game that either help you gather tomatoes, protect your stash of tomatoes, or attack the other players. And the tomatoes in the game are little fuzzy balls that you smash into your basket. This may be one of the draws of the game for Caleb, but I think he loves it mostly because he gets to cause havoc on the other players.

With young kids, their favorites are often dictated by what they?re doing at the moment. If you ask them what their favorite food is while eating corn dogs, they?ll probably says it?s corn dogs.

So with Caleb?s list, I made sure to question him well on it in order to eliminate this type of bias. I also let the list simmer a bit and went back to it with him a few days later to make sure. And with all that, these are his definite Top 10 Best Board Games and Card Games (at least for this year).

What board games and card games do your boys love to play?

?

Source: http://www.theboardgamefamily.com/2012/11/top-10-best-board-games-caleb/

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Sen. Saxby Chambliss May Face Conservative Challenge

Republican Sen. Saxby Chambliss of Georgia has been blunt in his thoughts on the so-called Norquist pledge, an agreement not to raise taxes, period. Chambliss has said he's willing to violate that pledge to avoid the fiscal cliff.

"I care more about my country than I do about a 20-year-old pledge," Chambliss told WMAZ-TV of Macon, Ga., in an interview before the Thanksgiving holiday.

Chambliss took a shot at conservative budget maven Grover Norquist who created the pledge and is pressuring conservatives to stick to their pledge.

"If we do it his way then we'll continue in debt, and I just have a disagreement with him about that," Chambliss said.

The pledge is very popular with the conservative base of the Republican Party, and it appears the conservative senator, who is up for re-election in 2014, could pay a political price in the form a primary challenge.

Erick Erickson, a conservative commentator, radio host and blogger who heads up RedState.com, announced on his radio show on Tuesday evening that he had been approached about challenging Chambliss and that he was going to give the idea "prayerful consideration."

Erickson, 37, hosts a radio talk-show on Atlanta's WSB-AM, and in 2007 he was elected to the city council in Macon. He resigned his post in 2011 to take the WSB-AM job.

In a blog post on Tuesday, Erickson ripped into Chambliss and expressed his hope that someone would challenge the Senator in a primary.

"Saxby Chambliss has been part of the problem and remains part of the problem," he wrote. "?we here in Georgia should convince Saxby that we are a problem - his problem in his path to re-election. We can and should make him fight for it and, the Good Lord willing, drive him from office in 2014."

Another Georgia Republican, former Secretary of State Karen Handel, has also said that she is considering challenging Chambliss. Georgia is a solidly Republican state, so the GOP primary is likely going to be the only competitive statewide contest in the state in 2014. The Republican candidate will be heavily favored to win the general election.

Also Read

Source: http://news.yahoo.com/sen-saxby-chambliss-may-face-conservative-challenge-171817273--abc-news-politics.html

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Digital society from the bottom up - Harvard News Office - Harvard ...

As communications takes an increasingly central role in the postindustrial economy worldwide, the transition to a digital society is threatening those at the bottom ? and could marginalize people of color, a University of Southern California scholar said Tuesday as he opened the three-part fall W.E.B. Du Bois Lecture Series, ?Exclusions and Inequality in Digital Societies: Theories, Evidence, and Strategy.?

Defining the gap simply by access to the Internet ?is the old digital divide,? said Ernest J. Wilson III, the Walter Annenberg Chair in Communication and dean of the Annenberg School for Communication and Journalism. ?The new digital divide is ownership, control, and content.?

Wilson described a ?scissor effect,? in which minority ownership, control, and content in the media has decreased in lockstep with the growth of media importance. In 2009, he said, African-Americans owned 1 percent of broadcast assets; today, that number has shrunk to 0.7 percent.

?We should care about this because we are citizens and these are matters of the life and death of democracy,? he said. ?There is no democracy without a free press. The free flow of information is essential to a democracy, and with the death of so many newspapers it is not clear that we have a healthy flow? in which issues important to minority classes are responsibly reported, and correspondingly addressed.

Wilson identified unequal access to capital as a primary factor in the new digital divide, but said other considerations needed to be examined: ?Is this a problem of a pipeline, with not enough people in the pipeline? Is it a problem of a glass ceiling? Is it a problem of a club? Is it a problem of mentoring?? he asked the Barker Center audience.

Wilson said the lectures were intended to begin a dialogue, to which end he has started a website. There he has posted four questions ? including how the introduction of new social media and other communication technologies has affected the African-American community, and what their impact has been on African-American engagement with other communities ? as well as responses from authorities such as NAACP President Benjamin Todd Jealous and Michael Copps of Common Cause. He also encourages responses on Twitter, @Digital_Du_Bois, and he urged feedback from those attending the lectures.

?African-American status in a knowledge society may not be a happy picture in the future. We in this room need to prevent a dystopian future,? he said.

Wilson provided his own five-point response to the question he posed others ? what would W.E.B. Du Bois say about the information revolution?

?Whatever the answer is, it has to be based on sound empirical evidence,? he said. ?It would require rethinking, and perhaps rewriting, perceived conceptual frameworks. Matters of exclusion, oppression, and discrimination, especially by race, must be front and center. All of this must lead to purposeful and progressive action. Finally, we should be aware at all times that we are operating in a global environment.

?The point I want to make is that we?re in a tough place,? Wilson said. ?[But] there are these weird moments in time [when] there is a coincidence of a bunch of scholars working on an issue and a federal, state, or public actor who wants to know about it and in turn there is a political world, instead of political actors, who need that information. We happen to be in one of those moments right now.?

The W.E.B. Du Bois Institute for African and African American Research?s series continues today with ?Policy Responses to Digital Inequality: Beyond Economics? and concludes Thursday with ?Structure, Agency and Culture in Digital Societies: Struggles at Home and Abroad.? Lectures are free and open to the public and begin at 4 p.m. in the Thompson Room of the Barker Center, 12 Quincy St., Cambridge.

Source: http://news.harvard.edu/gazette/story/2012/11/digital-society-from-the-bottom-up/

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Check Out the 2013 Kitchen & Bath Planner from Atlanta Home ...

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Home / Featured, Tips / Check Out the 2013 Kitchen & Bath Planner from Atlanta Home Improvement Magazine!

Are you thinking about remodeling the kitchen or a bathroom in your Atlanta area home in 2013? If so, it is time to start planning if you haven?t begun to do so!

With so many decisions to make along the way, even before consulting with a contractor or designer, you may find yourself a little overwhelmed, but our friends at Atlanta Home Improvement magazine have created a great resource to help you out ? the 2013 Kitchen & Bath Planner. This handy planner serves as a project workbook and guide and is chock full of beneficial information. Below are a few of the highlights of the 2013 Kitchen & Bath Planner:

  • The Project Workbook ? A questionnaire designed to help you determine your wants and needs.
  • The Top 10 Kitchen & Bath Trends ? A look at the top trends of 2012 from the National Kitchen & Bath Association.
  • The Budget Planner ? This chart breaks down the average costs of various features of a remodel into three categories ? Economical, Mid-Range, and High-End.
  • Remodeling Preferences ? Learn what other homeowners in the area have included in their remodeling projects.

The 2013 Kitchen & Bath Planner is certainly a resource worth looking at if you are entertaining the thought of a kitchen or bath remodel within the next year. Visit the Atlanta Home Improvement website to download a copy today.

And of course, once you have started your project and are ready to start selecting kitchen and bath fixtures, be sure to visit European Sink Atlanta. We offer a wide range of products from the top manufacturers in the industry. Visit our website or give us a call at 877-495-4421 for more information.

Image from Atlantahomeimprovement.com

Source: http://blog.europeansinkatlanta.com/featured/check-out-the-2013-kitchen-bath-planner-from-atlanta-home-improvement-magazine/

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Solid Internet Marketing Techniques For The Beginner ? DataGlove ...

Working to build a site to market your products, can be overwhelming. Trying to determine what will attract customers to your site can be a challenging task. Some tips and ideas are listed below that will help you with this task.

For your online business try the ?bill me later? option. Many customers like to pay right away. But there?s other?s who want to pay over a period of time. See if this option works for generating more sales and traffic to your website. You can do a trial period to determine if this works for you.

Making people aware of both the advantages and disadvantaged of your advertised product can make your audience trust your claims more. While you shouldn?t make the negatives of your product sound too bad, putting them in with the positives (which should be exaggerated somewhat) is a great way to earn your audience?s trust.

When you send a purchase to a customer by mail, consider including a sample in the box of a new product. For example, if you just got in some new long-lasting batteries you could include a pair in the box to run the electronics the person has bought. It?s a great way for them to test it out.

Use local business directories. Many online business directories will provide free listings. Get your business listed on as many as possible to attract more visitors to your site. Search for the directories that offer free listings, since there is no need to pay for something that you can get for free.

If you intend to spend money on your internet marketing efforts, go after traffic using the appropriate strategies. Pay-per-click (PPC) search engines will turn your money into favorable search rankings. Affiliate marketing programs will pay off other websites for driving traffic to yours. Once you decide to spend money for traffic, make sure you get the most bang for your buck.

Build other websites that revolve around your primary product or subject. Do not create websites that are junk. Take your time and include relevant information. This will keep people at your website longer, and you will be able to trust the links to your website, which is where you will bring in customers and make money.

Make a website for your business. This should be one of the first steps to market your business using the Internet. By setting up a website that is online you can expand your business because you will be able to reach more customers. This also makes it easier for existing customers to find you.

If your business is linked to affiliate businesses, consider brainstorming with other business owners. Combining thoughts and products, will help build exposure for both businesses and boost customer loyalty to both. If the business you choose to work with is competition, choose a neutral product that will not give them an edge.

Use color on your web page. A plain white web page is unlikely to do as much business as one that has an eye-catching color. Experiment a little to see what works best for you and the type of business that you are running. You can also change the style and size of the wording on your page, which will help to draw customers in.

After you get past all the scams out there and realize that internet marketing follows a logical path and not a miraculous one, you can begin to build a solid business. Follow this advice and you will start to turn your ideas into money. Eventually, you might just hit that six-figure mark.

This Trevo Review explains why this is a great internet business that allows you to work from home.

Source: http://www.dataglove.ch/solid-internet-marketing-techniques-for-the-beginner/5889/

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Tuesday, November 27, 2012

Metabolic protein launches sugar feast that nurtures brain tumors

ScienceDaily (Nov. 26, 2012) ? Researchers at The University of Texas MD Anderson Cancer Center have tracked down a cancer-promoting protein's pathway into the cell nucleus and discovered how, once there, it fires up a glucose metabolism pathway on which brain tumors thrive.

They also found a vital spot along the protein's journey that can be attacked with a type of drug not yet deployed against glioblastoma multiforme, the most common and lethal form of brain cancer. Published online by Nature Cell Biology, the paper further illuminates the importance of pyruvate kinase M2 (PKM2) in cancer development and progression.

"PKM2 is very active during infancy, when you want rapid cell growth, and eventually it turns off. Tumor cells turn PKM2 back on -- it's overexpressed in many types of cancer," said Zhimin Lu, M.D., Ph.D., the paper's senior author and an associate professor in MD Anderson's Department of Neuro-Oncology.

Lu and colleagues showed earlier this year that PKM2 in the nucleus also activates a variety of genes involved in cell division. The latest paper shows how it triggers aerobic glycolysis, processing glucose into energy, also known as the Warburg effect, upon which many types of solid tumors rely to survive and grow.

"PKM2 must get to the nucleus to activate genes involved in cell proliferation and the Warburg effect," Lu said. "If we can keep it out of the nucleus, we can block both of those cancer-promoting pathways. PKM2 could be an Achilles' heel for cancer."

By pinpointing the complicated steps necessary for PKM2 to penetrate the nucleus, Lu and colleagues found a potentially druggable target that could keep the protein locked in the cell's cytoplasm.

MEK, ERK emerge as targets

The process begins when the epidermal growth factor connects to its receptor on the cell surface.

This leads to:

* Activation of the MEK protein, which in turn activates ERK.

* ERK sticking a phosphate group to a specific spot on PKM2.

* Phosphorylation priming PKM2 for a series of steps that culminate in its binding to the protein importin, which lives up to its name by taking PKM2 through the nuclear membrane.

Once in the nucleus, the team showed that PKM2 activates two genes crucial to aerobic glycolysis and another that splices PKM RNA to make even more PKM2.

An experiment applying several kinase-inhibiting drugs to human glioblastoma cell lines showed that only a MEK/ERK inhibitor prevented EGF-induced smuggling of PKM2 into the nucleus. ERK activation then is mandatory for PKM2 to get into the nucleus.

"MEK/ERK inhibitors have not been tried yet in glioblastoma multiforme," Lu said. Phosporylated PKM2 is a potential biomarker to identify patients who are candidates for MEK/ERK inhibitors once those drugs are developed.

MEK inhibitor blocks tumor growth

The researchers also found that the two glycolysis genes activated by PKM2, called GLUT1 and LDHA, are required for glucose consumption and conversion of pyruvate to lactate, crucial factors in the Warburg Effect. Depleting PKM2 in tumor cell lines reduced glucose consumption and lactate production.

In mice, depleting PKM2 blocked the growth of brain tumors. Re-expressing the wild type protein caused tumors to grow. However, re-expression of a PKM2 mutant protein that lost its ability to get into the nucleus failed to promote tumor formation. Experiments in human glioblastoma cell lines showed the same effect.

Injecting the MEK inhibitor selumetinib into tumors inhibited tumor growth, reduced ERK phosphorylation, PKM2 expression and lactate production in mice. In 48 human tumor samples, the team found that activity of EGFR, ERK1/2 and PKM2 were strongly correlated.

Cause of PKM2 overexpression

Lu and colleagues also published a paper in Molecular Cell that revealed a mechanism for overexpression of PKM2 in glioblastoma. They found that EGF receptor activation turns on NF-KB, which leads to a series of events culminating in PKM2 gene activation.

PKM2 levels were measured in tumor samples from 55 glioblastoma patients treated with standard of care surgery, radiation and chemotherapy. The 20 with low PKM2 expression had a median survival of 34.5 months, compared to 13.6 months for the 35 patients with high levels of PKM2.

Level of PKM2 expression in 27 low-grade astrocytomas was about half of the expression found in higher grade glioblastomas.

"In these two papers, we show how PKM2 is overexpressed in tumors, how it gets into the nucleus, that nuclear entry is essential to tumor development, and identified potential drugs and a biomarker that could usefully treat people," Lu said.

Co-authors of the Nature Cell Biology paper are first author Weiwei Yang, Ph.D., Yanhua Zheng, Ph.D., Yan Xia, Ph.D., and Haitao Ji, Ph.D., of MD Anderson's Department of Neuro-Oncology and Brain Tumor Center; Xiaomin Chen, Ph.D., of MD Anderson's Department of Biochemistry and Molecular Biology; Ken Aldape, M.D., MD Anderson's Department of Pathology; Fang Guo, Ph.D., Nanomedicine Center, Shanghai Research Institute, China Academy of Science; Costas Lyssiotis, Ph.D., and Lewis Cantley, Ph.D., Beth Israel Deaconess Medical Center, Harvard Medical School.

This research was funded by grants from the National Institutes of Health (numbers 2RO1CA109035, RO1GM068566 and RO1GM56302), MD Anderson's Cancer Center Support Grant (CA16672) from the National Cancer Institute; and a research grant from the Cancer Prevention and Research Institute of Texas.

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Story Source:

The above story is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaomin Chen, Fang Guo, Costas A. Lyssiotis, Kenneth Aldape, Lewis C. Cantley, Zhimin Lu. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology, 2012; DOI: 10.1038/ncb2629

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/_dUZzBAdjxE/121126164003.htm

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