lern2play Resources and Information. This website is for sale!

By using our site, you consent to this privacy policy: This website allows third-party advertising companies for the purpose of reporting website traffic, statistics, advertisements, "click-throughs" and/or other activities to use Cookies and /or Web Beacons and other monitoring technologies to serve ads and to compile anonymous statistics about you when you visit this website. Cookies are small text files stored on your local internet browser cache. A Web Beacon is an often-transparent graphic image, usually no larger than 1 pixel x 1 pixel that is placed on a Web site. Both are created for the main purpose of helping your browser process the special features of websites that use Cookies or Web Beacons. The gathered information about your visits to this and other websites are used by these third party companies in order to provide advertisements about goods and services of interest to you. The information do not include any personal data like your name, address, email address, or telephone number. If you would like more information about this practice and to know your choices about not having this information used by these companies, click here.

Source: http://feeds.feedburner.com/lern2play

brad miller chandler jones peyton hillis fletcher cox charlotte bobcats new york rangers nfl mock draft 2012

Altering eye cells may one day restore vision

Jan. 25, 2013 ? Doctors may one day treat some forms of blindness by altering the genetic program of the light-sensing cells of the eye, according to scientists at Washington University School of Medicine in St. Louis.

Working in mice with retinitis pigmentosa, a disease that causes gradual blindness, the researchers reprogrammed the cells in the eye that enable night vision. The change made the cells more similar to other cells that provide sight during daylight hours and prevented degeneration of the retina, the light-sensing structure in the back of the eye. The scientists now are conducting additional tests to confirm that the mice can still see.

"We think it may be significantly easier to preserve vision by modifying existing cells in the eye than it would be to introduce new stem cells," says senior author Joseph Corbo, MD, PhD, assistant professor of pathology and immunology. "A diseased retina is not a hospitable environment for transplanting stem cells."

The study is available in the early online edition of Proceedings of the National Academy of Sciences.

Mutations in more than 200 genes have been linked to various forms of blindness. Efforts are underway to develop gene therapies for some of these conditions.

Rather than seek treatments tailored to individual mutations, Corbo hopes to develop therapies that can alleviate many forms of visual impairment. To make that possible, he studies the genetic factors that allow cells in the developing eye to take on the specialized roles necessary for vision.

The retina has two types of light-sensing cells or photoreceptors. The rods provide night vision, and the cones sense light in the daytime and detect fine visual details.

In retinitis pigmentosa, the rods die first, leaving patients unable to see at night. Daytime vision often remains intact for some time until the cones also die.

Corbo and others have identified several genes that are active in rods or in cones but not in both types of photoreceptors. He wondered whether turning off a key gene that is activated only in rods could protect the cells from the loss of vision characteristic of retinitis pigmentosa.

'"The question was, when retinitis pigmentosa is caused by a mutation in a protein only active in rods, can we reduce or stop vision loss by making the cells less rod-like?" he explains.

The new study focuses on a protein known as Nrl, which influences development of photoreceptors. Cells that make Nrl become rods, while cells that lack the protein become cones. Turning off the Nrl gene in developing mice leads to a retina packed with cone cells.

To see if this rod-to-cone change was possible in adult mice, Corbo created a mouse model of retinitis pigmentosa with an Nrl gene that could be switched on and off by scientists.

"In adult mice, switching off Nrl partially converts the rod cells into cone cells," he says. "Several months later, when the mutant mice normally had very little vision left, we tested the function of their retina."

The test showed a healthier level of electrical activity in the retinas of mice that lacked Nrl, suggesting that the mice could still see.

Corbo now is looking for other critical development factors that can help scientists more fully transform adult rods into cones. He notes that if complete conversion of rods to cones were possible, this therapy could also be helpful for conditions where cone cells die first, such as macular degeneration.

Montana CL, Kolesnikov AV, Shen SQ, Myers CA, Kefalov VJ, Corbo JC. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proceedings of the National Academy of Sciences, online January 14, 2013.

Funding from the National Eye Institute (EY018826 and EY019312), an Institutional Vision Science Training Grant (EY13360) and a grant from Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences at Washington University supported this research.?

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by Washington University in St. Louis. The original article was written by Michael C. Purdy.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. C. L. Montana, A. V. Kolesnikov, S. Q. Shen, C. A. Myers, V. J. Kefalov, J. C. Corbo. Reprogramming of adult rod photoreceptors prevents retinal degeneration. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1214387110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/bmQWAsLKO80/130128104443.htm

terminator salvation deron williams jarhead montrose marshawn lynch earthquake bay area clear channel

Partial list of winners at 19th annual SAG Awards

LOS ANGELES (AP) ? MOVIES:

Supporting actor: Tommy Lee Jones, "Lincoln"

Supporting actress: Anne Hathaway, "Les Miserables"

Stunt ensemble: "Skyfall"

___

TELEVISION:

Actor in a movie or miniseries: Kevin Costner "Hatfields & McCoys"

Actress in a movie or miniseries: Julianne Moore, "Game Change"

Actor in a comedy series: Alec Baldwin, "30 Rock"

Actress in a comedy series: Tina Fey, "30 Rock"

Comedy series cast: "Modern Family"

Stunt ensemble: "Game of Thrones"

___

Life Achievement: Dick Van Dyke

Source: http://news.yahoo.com/partial-list-winners-19th-annual-sag-awards-021225006.html

rick perry travis barker get back on board rob lowe peyton manning what is sopa marianne gingrich ibooks author

NFC blows out AFC 62-35 in Pro Bowl in Hawaii

Houston Texans defensive end J.J. Watt (99) of the AFC attempts to chase down Seahawks quarterback Russell Wilson (3) of the NFC in the third quarter of the NFL Pro Bowl football game in Honolulu, Sunday, Jan. 27, 2013. (AP Photo/Eugene Tanner)

Houston Texans defensive end J.J. Watt (99) of the AFC attempts to chase down Seahawks quarterback Russell Wilson (3) of the NFC in the third quarter of the NFL Pro Bowl football game in Honolulu, Sunday, Jan. 27, 2013. (AP Photo/Eugene Tanner)

Kansas City Chiefs outside linebacker Tamba Hali (91) of the AFC and his teammate strong safety Eric Berry (29) tackle Minnesota Vikings tight end Kyle Rudolph (82) of the NFC in the second quarter of the NFL Pro Bowl football game in Honolulu, Sunday, Jan. 27, 2013. (AP Photo/Eugene Tanner)

New York Giants quarterback Eli Manning (10) of the NFC makes a pass during the second quarter of the NFL Pro Bowl football game in Honolulu, Sunday, Jan. 27, 2013. (AP Photo/Marco Garcia)

Denver Broncos quarterback Peyton Manning (18) hands off the football to Houston Texans running back Arian Foster (23) of the AFC in the first quarter of the NFL football Pro Bowl game against the NFC in Honolulu, Sunday, Jan. 27, 2013. (AP Photo/Eugene Tanner)

Houston Texans quarterback Matt Schaub (8) of the AFC manages to throw a pass just as Minnesota Vikings defensive end Jared Allen (69) of the NFC grabs Schaub during the third quarter of the NFL Pro Bowl football game in Honolulu, Sunday, Jan. 27, 2013. (AP Photo/Eugene Tanner)

HONOLULU (AP) ? A handful of shenanigans and plenty of points ? yet still another ho-hum Pro Bowl.

Whether the NFL's all-star game will return next season is something the league will ponder the next few months after the NFC's 62-35 blowout of the AFC on Sunday.

"It's been an unbelievable week," Seattle rookie quarterback Russell Wilson said, "And the thing was, if you watched us, everybody was competing today and it was really awesome."

Wilson at least got the crowd pumped up in the second half with some nifty scrambles and three passing touchdowns. There was also Houston's sack-happy defensive end J.J. Watt going out for a couple of passes as a wide receiver, and retiring Green Bay center Jeff Saturday snapping to two Mannings on opposite teams.

But while the NFC appeared unstoppable on offense, with nearly each player putting up fantasy-worthy lines in limited play, the AFC had five turnovers and scored most of its points well after the game was no longer competitive.

Minnesota tight end Kyle Rudolph was voted the game's MVP with five catches for 122 yards and a touchdown.

"Guys were competing, guys wanted to win and guys want to keep the game here," Rudolph insisted. "That was the point before the game. We want to keep this game rolling for future Pro Bowlers."

Watt, who had 20 1/2 sacks for Houston, lined up as a wide receiver on the AFC's third play from scrimmage, but missed a pass from Denver quarterback Peyton Manning. He was targeted one more time, but didn't make a catch.

He later showed a television camera a bloody left pinkie, joking with NBC broadcasters that it was proof that the players were trying.

"Hey, Commish, we're playing hard," Watt said as he showed his finger.

Roger Goodell has said the Pro Bowl won't be played again if play didn't improve this year. Last year, fans in Hawaii booed as lineman were clearly not trying. On one play in that game, Minnesota defensive end Jared Allen did a barrel roll to switch positions with a teammate.

If players were coasting this time around, it was less obvious. The AFC just played poorly. And fans didn't boo much ? the stands were relatively empty even though the game sold enough tickets to lift a local television blackout.

The game was trending on Twitter in the United States early on, but quickly gave way to the Screen Actors Guild Awards and the WWE Royal Rumble.

Saturday, retiring at the end of this season, played for both teams, though he came representing the NFC. He lined up on one play for the AFC to snap the ball one last time to Manning, his longtime former Colts teammate.

Saturday said it meant a lot to him that the Broncos quarterback, whom Saturday called a true friend, orchestrated the stunt.

"He's got a little more pull than I got," Saturday said. "He got it all set up and timed up for me, so it was really nice of him to do that."

Saturday played 13 seasons in Indianapolis, all with Manning ? except 2011, when Manning was out with a neck injury. Saturday then played later in the game for the NFC, snapping to Peyton's brother, Giants quarterback Eli Manning.

Saturday's last play on the field was a passing touchdown by Eli Manning.

Peyton Manning said it was nice for the NFL to allow the play to happen.

"It's something that I'll always remember," he said, "that he'll always remember to kind of get that one, final snap together after the thousands that we've taken together."

Even as the NFC piled up touchdowns, the game struggled for memorable moments after Saturday's momentary switch.

In the second quarter, referee Ed Hochuli drew cheers when announcing a pass interference penalty on Denver cornerback Champ Bailey in the second quarter ? the first flag of the game.

"Yes, there are penalties in the Pro Bowl," Hochuli said, drawing laughs and loud cheers.

Giants wideout Victor Cruz broke a Pro Bowl record with 10 catches. Tampa Bay receiver Vincent Jackson had 91 yards and two touchdowns. Eli Manning threw for 191 yards and two touchdowns.

Cincinnati's A.J. Green had three TD catches for the AFC.

NFL officials said earlier in the week that the league wants to decide the future of the Pro Bowl by the time next season's schedule is released in April.

"We understood exactly what (Goodell) wanted, guys were making plays all over the field," Cruz said. "There was a little bit more high intensity than in years past and we were excited to play."

___

Oskar Garcia can be reached on Twitter at http://twitter.com/oskargarcia .

___

Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-01-28-Pro%20Bowl/id-6a35d20a5b734f668200f2650a502a00

nba all star game 2012 academy awards 2012 nominations academy awards independent spirit awards 2012 jan brewer independent spirit awards 2012 oscar predictions

Bahrain police, mourners clash after boy's funeral

MANAMA, Bahrain (AP) ? Riot police and mourners have clashed in Bahrain following the funeral of an 8-year-old boy whom opposition groups claim died from respiratory problems triggered by heavy tear gas.

Officials did not immediately comment on the cause of the boy's death after he was hospitalized Jan. 19.

Rights groups and others have complained about intense tear gas use by Bahraini forces during nearly two years of unrest.

Hundreds of mourners staged a protest march following Sunday's burial, but were dispersed by riot police firing tear gas and stun grenades. Some protesters hurled firebombs.

Bahrain has been wracked by conflict between the Sunni-led monarchy and majority Shiites seeking a greater political voice.

More than 55 people have died in the unrest in the strategic kingdom, home to the U.S. Navy's 5th Fleet.

Source: http://news.yahoo.com/bahrain-police-mourners-clash-boys-funeral-160130827.html

Emanuel Steward college board nyc.gov SAT Notre Dame Football Schedule detroit tigers Tsunami

2 policemen killed after Egypt soccer verdict

CAIRO (AP) ? Egyptian security officials say a senior police officer and a policeman were shot dead in the Mediterranean city of Port Said after a judge sentenced 21 people to death in connection to one of the world's deadliest incidents of soccer violence.

Officials say that the police were killed when relatives tried to break into the Port Said prison to free the 73 defendants in the case held there.

At least 75 people were wounded in Saturday's violence outside the prison. Port Said residents also cut off the main road leading to the city.

Officials spoke anonymously in line with regulations.

The violence comes after a judge sentenced fans of Port Said's Al-Masry team to death for taking part in the Feb. 1, 2012, soccer violence, which killed 74 fans of Cairo's Al-Ahly club.

Source: http://news.yahoo.com/2-policemen-killed-egypt-soccer-verdict-095858340.html

etch a sketch the host hoodie hoosiers temperance world bank kim kardashian flour bomb

Bandwidth-sharing app brings connectivity to all

MAXED out on your phone's data plan? Stuck in a dead zone? Your neighbour can help. A new app lets users share mobile internet connections with anyone around them, helping the data-starved avoid roaming charges and steep overage fees.

Called AirMobs, the app shares a phone's data plan with others through the phone's Wi-Fi signal. For every kilobyte shared, AirMobs awards a data credit that can be used later.

"The idea is to extend the principle of 'give and you shall receive' to create an incentive for people to share their data plan," says Eyal Toledano at the Massachusetts Institute of Technology, who developed the app.

AirMobs aims to help users avoid high charges by connecting to the internet via the phones around them. In places where perhaps only one carrier has coverage, it can provide connectivity for all.

"You can use your credit in an area where you don't have a connection," Toledano says. "Maybe the guy next to you has great coverage."

Users can choose how much of their data plan they share. AirMobs runs in the background, regularly checking the phone's battery life and the strength of the cellular connection. It also detects movement, as the signal is more stable when the phone is stationary. When conditions are right, the Wi-Fi transmitter switches on automatically, and others can then connect.

Toledano says he has successfully tested the system within MIT, but he is hesitant to release it to the Google Play Store for fear that cellular carriers will object.

Bill Menezes, an analyst at Gartner in Denver, Colorado, agrees that's a danger. "Verizon Wireless, for example, specifically prohibits resale of its services to a third party," he says. "The question is how they would enforce it against an app like this."

"If networks decided to collaborate and let all devices roam freely, AirMobs would be less needed," Toledano says. "But where operators aren't collaborating, user-to-user collaboration can fix the situation."

If you would like to reuse any content from New Scientist, either in print or online, please contact the syndication department first for permission. New Scientist does not own rights to photos, but there are a variety of licensing options available for use of articles and graphics we own the copyright to.

Have your say

Only subscribers may leave comments on this article. Please log in.

Only personal subscribers may leave comments on this article

Subscribe now to comment.

All comments should respect the New Scientist House Rules. If you think a particular comment breaks these rules then please use the "Report" link in that comment to report it to us.

If you are having a technical problem posting a comment, please contact technical support.

Source: http://feeds.newscientist.com/c/749/f/10897/s/27ebc825/l/0L0Snewscientist0N0Carticle0Cmg217290A150B90A0A0Ebandwidthsharing0Eapp0Ebrings0Econnectivity0Eto0Eall0Bhtml0Dcmpid0FRSS0QNSNS0Q20A120EGLOBAL0Qonline0Enews/story01.htm

red tails red tails heidi klum heidi klum red tails trailer joe pa dead laura dekker